HUMAN IMMUNOLOGY

The journal's scope includes understanding the genetic and functional mechanisms that distinguish human individuals in their immune responses to allografts| pregnancy| infections or vaccines as well as the immune responses that lead to autoimmunity| allergy or drug hypersensitivity. It also includes examining the distribution of the genes controlling these responses in populations. Research areas include: Studies of the genetics| genomics| polymorphism| evolution| and population distribution of immune-related genes Studies of the expression| structure and function of the products of immune-related genes Immunogenetics of susceptibility to infectious and autoimmune disease| and allergy The role of the immune-related genes in hematopoietic stem cell| solid organ| and vascularized composite allograft transplant Histocompatibility studies including alloantibodies| epitope definition| and T cell alloreactivity Studies of immunologic tolerance and pregnancy T cell| B cell| NK and regulatory cell functions| particularly related to subjects within the journal's scope Pharmacogenomics and vaccine development in the context of immune-related genes Human Immunology considers immune-related genes to include those encoding classical and non-classical HLA| KIR| MIC| minor histocompatibility antigens (mHAg)| immunoglobulins| TCR| BCR| proteins involved in antigen processing and presentation| complement| Fc receptors| chemokines and cytokines. Other immune-related genes may be considered. Human Immunology is also interested in bioinformatics of immune-related genes and organizational topics impacting laboratory processes| organ allocation| clinical strategies| and registries related to autoimmunity and transplantation.

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